Microinjection of sanguinarine into the ventrolateral orbital cortex inhibits Mkp-1 and exerts an antidepressant-like effect in rats
Section snippets
Conflict of interest
None.
Acknowledgements
This work was supported by National Natural Science Foundation of China (30700259 to Yunchun Chen, 30870886 to Qingrong Tan) and the National Science and Technology Program of China (2009BAI77B06 to Qingrong Tan).
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2019, NeuronCitation Excerpt :Neuroimaging studies suggest that VLO activity is linked to states of consciousness (Englot et al., 2009). Additionally, the VLO is linked to spatial navigation and attention (Corwin et al., 1994; Feierstein et al., 2006; King et al., 1989), depression (Chen et al., 2012; Lin et al., 2012; Xing et al., 2011), memory formation (Zhao et al., 2013), and risk assessment (Eshel et al., 2007). The broad involvement of VLO across cognitive and behavioral processes suggests that it influences multiple brain-wide circuits.
MicroRNA-101 in the ventrolateral orbital cortex (VLO) modulates depressive-like behaviors in rats and targets dual-specificity phosphatase 1 (DUSP1)
2017, Brain ResearchCitation Excerpt :Moreover, positive and negative emotional signals are differentially processed in distinct subregions of the OFC (Northoff et al., 2000). Among those subregions, the ventrolateral orbital cortex (VLO) is strongly implicated in the pathogenesis of mood disorders, such as depression (Chen et al., 2012; Lin et al., 2012), as well as in nociception (Dang et al., 2011) and stress-related memory (Zhao et al., 2013). Recent studies by our group and others have demonstrated that VLO is involved in regulating depressive-like behaviors in rodents.
Electrolytic lesions of the bilateral ventrolateral orbital cortex inhibit methamphetamine-associated contextual memory formation in rats
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