Regular articleAmygdala modulation of parahippocampal and frontal regions during emotionally influenced memory storage
Section snippets
Experimental procedures
Data for the present study were taken from Cahill et al. (2001). Details of the experimental design are given in this study and in Cahill et al. (1996). Briefly, 11 healthy, right-handed males (average age = 21.5 ± 0.88 years) underwent two PET scans while watching a series of film clips. Exclusionary criteria included any major medical or psychiatric illness, substance abuse, or history of head injury. The PET sessions were separated by 2–7 days. During one scan, subjects viewed 12 emotionally
Behavioral results
Subjects recalled an average of 2.1 (± 0.6) neutral films and 5.73 (± 0.8) emotional films. The average arousal rating for the neutral film clips was 2.8 (± 0.5) and for the emotional film clips was 5.2 (± 0.5). Subjects recalled significantly more emotional films than neutral films [t(10) = 4.1, P < .002] and rated the emotional films as significantly more arousing than the neutral films [t(10) = 3.2, P < .01].
Functional connectivity of the right amygdala
The first LV produced by the seed-PLS (accounting for 81% of the cross-block
Discussion
This experiment tested the hypothesis that increased efferent influences from the amygdala to other brain regions, and in particular to the parahippocampal region, will occur in emotionally arousing compared with emotionally neutral learning conditions. Consistent with this hypothesis, results from an SEqM analysis of PET data revealed a significantly more positive amygdala influence on two brain regions—the parahippocampal gyrus and Brodmann's area 47—during the emotional relative to the
Acknowledgements
We greatly appreciate the expert and detailed anatomical advice offered by James Fallon in the creation of the neuroanatomical model and our wonderful path analysis consultant Randy McIntosh. Funded by NIMH Grant MH57508 to L.C.
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