Neuron
Volume 68, Issue 4, 18 November 2010, Pages 739-749
ArticleSensing Muscle Ischemia: Coincident Detection of Acid and ATP via Interplay of Two Ion Channels
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Highlights
► Transient micromolar ATP doubles ASIC currents on metaboreceptors for minutes ► ATP acts through P2X receptors but flux through P2X channels appears irrelevant ► FRET and P2X receptor independence argue that P2X and ASIC form a complex ► Only P2X5 mimics all aspects of the native response on sensory neurons
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These authors contributed equally to this work
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Present address: Departamento de Ciencias Fisiológicas, Universidad del Valle, Cali, Colombia
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Present address: Departamento de Fisiologia e Biofísica, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brasil
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Present address: Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA
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