Neuron
Volume 77, Issue 4, 20 February 2013, Pages 667-679
ArticleTRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids
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Highlights
► TRPV1 is intrinsically heat sensitive ► TRPV1 is negatively regulated by phosphoinositide lipids ► Bioactive lipids serve as direct TRPV1 ligands ► TRPV1 C terminus tunes channel sensitivity through interaction with membrane lipids
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