Abstract
Indomethacin microspheres based on a combination of ethylcellulose and polyethyleneglycol were prepared using the solvent evaporation process. Release profiles of ensemble and individual microspheres were measured. Both were found to follow first-order kinetics, in contrast to what was expected. This was attributed to the fact that all the particles showed the same kinetic pattern and had a greater degree of homogeneity in the payload, mean particle size and shape, and k l values than in ensembles of microcapsules.
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Benita, S., Babay, D., Hoffman, A. et al. Relation Between Individual and Ensemble Release Kinetics of Indomethacin from Microspheres. Pharm Res 5, 178–182 (1988). https://doi.org/10.1023/A:1015917023949
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DOI: https://doi.org/10.1023/A:1015917023949