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Post-Translational Modifications of β Subunits of Voltage-Dependent Calcium Channels

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Abstract

Different post-translational modifications of Ca channel β subunits have been identified. Recent studies have characterized the palmitoylation of the Ca channel β2a subunit, as well as one effect of this modification on channel function. The potential importance of palmitoylation on other channel properties is discussed. Other studies have addressed the role of phosphorylation of β subunits in the regulation of voltage-dependent Ca channels. Phosphorylation of β subunits by second messenger-activated protein kinases, as well as by unidentified protein kinases, may affect interactions between channel subunits and other aspects of channel function. The differential modification of Ca channel β subunit isoforms by post-translational events likely results in diversely regulated channels with unique properties.

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Chien, A.J., Hosey, M.M. Post-Translational Modifications of β Subunits of Voltage-Dependent Calcium Channels. J Bioenerg Biomembr 30, 377–386 (1998). https://doi.org/10.1023/A:1021941706726

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