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Enzymic Content of the Mitochondria Fraction

Abstract

A LARGE number of enzymes have been located in the mitochondria fraction isolated by means of differential centrifugation; this fact is generally assumed to indicate that they are structurally associated within the living cell. Recent studies, part of which were presented at the second International Congress of Biochemistry1, have shown that this conclusion is not necessarily warranted. It has been found that the acid phosphatase of rat liver, which comes down predominantly with the large granules in a form which, in the native particles, is practically devoid of activity towards added glycerophosphate at pH 5 2–4, does not belong to the same type of granules as cytochrome oxidase.

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References

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DUVE, C., GIANETTO, R., APPELMANS, F. et al. Enzymic Content of the Mitochondria Fraction. Nature 172, 1143–1144 (1953). https://doi.org/10.1038/1721143a0

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