Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Actions of Thrombin and Other Coagulant and Proteolytic Enzymes on Blood Platelets

Abstract

The action of thrombin on fibrinogen is not responsible for its effect on platelets. Thrombin does, however, have an enzyme effect on a platelet constituent: this requires an unsubstituted serine hydroxyl group and a group susceptible to acetylation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Purchase on Springer Link

Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Laki, K., and Gladner, J. A., Physiol. Rev., 44, 127 (1964).

    Article  CAS  Google Scholar 

  2. Davey, M. G., and Lüscher, E. F., in Proc. Third Meeting Fed. Europ. Biochem. Soc., Warsaw, 1966, Biochemistry of Blood Platelets, 9 (Academic Press, London and New York, 1967).

    Google Scholar 

  3. Morse, E. E., Jackson, D. P., and Conley, C. L., J. Clin. Invest., 44, 809 (1965).

    Article  CAS  Google Scholar 

  4. Mihalyi, E., and Godfrey, J. E., Biochim. Biophys. Acta, 67, 73 (1963).

    Article  CAS  Google Scholar 

  5. Blombäck, B., and Yamashima, I., Ark. Kemi, 12, 299 (1958).

    Google Scholar 

  6. Didisheim, P., and Lewis, J. H., Proc. Soc. Exp. Biol. and Med., 93, 10 (1956).

    Article  CAS  Google Scholar 

  7. Nahas, L., Denson, K. W. E., and Macfarlane, R. G., Thrombos. Diathes. Haemorrh., 12, 355 (1964).

    Article  CAS  Google Scholar 

  8. Davey, M. G., and Lüscher, E. F., Nature, 207, 730 (1965).

    Article  ADS  CAS  Google Scholar 

  9. Davey, M. G., and Lüscher, E. F., in Proc. Tenth Cong. Europ. Soc. Haemat., Strasbourg, 1965, 1118 (S. Karger, Basel, 1967).

    Google Scholar 

  10. Bettex-Galland, M., and Lüscher, E. F., Thrombos. Diathes. Haemorrh., 4, 178 (1960).

    Article  CAS  Google Scholar 

  11. Rosen, H., Arch. Biochem., 67, 10 (1957).

    Article  CAS  Google Scholar 

  12. Soulier, J. P., and Prou-Wartelle, O., Thrombos. Diathes. Haemorrh., 17, 321 (1967).

    Article  CAS  Google Scholar 

  13. Sherry, S., and Troll, W., J. Biol. Chem., 208, 95 (1954).

    CAS  PubMed  Google Scholar 

  14. Markwardt, F., Barthel, W., Glusa, E., and Hoffmann, A., Naunyn-Schmiedbergs Arch. Exp. Pathol. Pharmacol., 252, 297 (1966).

    Article  CAS  Google Scholar 

  15. Marcus, A. J., and Zucker, M. B., The Physiology of Blood Platelets, 63 (Grune and Stratton, New York, 1965).

    Google Scholar 

  16. Engel, A., and Alexander, B., Biochemistry, 5, 3590 (1966).

    Article  CAS  Google Scholar 

  17. Engel, A., Alexander, B., and Pechet, L., Biochemistry, 5, 1543 (1966).

    Article  CAS  Google Scholar 

  18. Lüscher, E. F., Ergebn. Physiol., 50, 1 (1959).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

DAVEY, M., LÜSCHER, E. Actions of Thrombin and Other Coagulant and Proteolytic Enzymes on Blood Platelets. Nature 216, 857–858 (1967). https://doi.org/10.1038/216857a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/216857a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing