Abstract
DURING certain normal immunisation schedules, suppressor cells are generated and act in suppressing the expression of delayed hypersensitivity reactions1,2. The suppression is immunologically specific and is dependent on living cells. We have suggested that the suppressor cells were B cells because they are depleted when 300 mg kgā1 cyclophosphamide (CY) is given 3 d before sensitisation3ā5.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Katz, S. I., Parker, D., Sommer, G., and Turk, J. L., Nature, 248, 612 (1974).
Neta, R., and Salvin, S. B., Cell. Immun., 9, 242 (1973).
Turk, J. L., and Poulter, L. W., Clin. exp. Immun., 10, 285 (1972).
Poulter, L. W., and Turk, J. L., Nature new Biol., 238, 17 (1972).
Turk, J. L., Parker, D., and Poulter, L. W., Immunology, 23, 493 (1972).
Blazkovec, A. A., Sorkin, E., and Turk, J. L., Int. Arch. Allergy, 27, 289 (1965).
Campbell, P. A., and Grey, H. M., Cell. Immun., 5, 171 (1972).
Russell, A. S., Liburd, E. M., and Diener, E., Nature, 249, 43 (1974).
Gorcynski, R., J. Immun., 112, 1826 (1974).
Kerckhaert, J. A. M., van den Berg, G. J., and Willers, J. M. N., Annales d' Immunologie, 125 C, 415 (1974).
Cantor, H., and Asofsky, R., J. exp. Med., 135, 764 (1972).
Gershon, R. K., Liebhaber, S., and Ryn, S., Immunology, 26, 909 (1974).
Zembala, M., and Asherson, G. L., Nature, 244, 227 (1973).
Taussig, M. J., Nature, 248, 236 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KATZ, S., PARKER, D. & TURK, J. B-cell suppression of delayed hypersensitivity reactions. Nature 251, 550ā551 (1974). https://doi.org/10.1038/251550a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/251550a0
This article is cited by
-
The role of regulatory B cells in immune regulation and childhood allergic asthma
Molecular and Cellular Pediatrics (2024)
-
FoxO1 suppresses IL-10 producing B cell differentiation via negatively regulating Blimp-1 expression and contributes to allergic asthma progression
Mucosal Immunology (2022)
-
Higher CD19+CD25+ Bregs are independently associated with better graft function in renal transplant recipients
BMC Nephrology (2021)
-
Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease
Cellular & Molecular Immunology (2021)
-
Granzyme BāProducing B Cells Function as a Feedback Loop for T Helper Cells in Liver Transplant Recipients with Acute Rejection
Inflammation (2021)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
