Abstract
THE detection of histamine H2-receptor antagonists1,2 has provided fresh impetus to the investigation of central effects of histamine3–7 and its possible role as a neurotransmitter3,8–10. In the hypothalamus of rat and cat microelectrophoretically applied histamine excites a large number of cells. This action, which is unique to the hypothalamus, is not selectively antagonised by the H1-receptor antagonist mepyramine or by the H2-receptor antagonist metiamide8,9. In the cortex of the cat several H1-antagonists were tested but no specific action could be demonstrated11. We report now on a selective antagonism of metiamide against depressant actions of histamine in the cerebral cortex of cat and rat.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Black, J. W., Duncan, W. A. M., Durant, C. J., Ganellin, C. R., and Parsons, E. M., Nature, 236, 385–390 (1972).
Black, J. W., Durant, G. J., Emmett, J. C., and Ganellin, C. R., Nature, 248, 65–67 (1974).
Baudry, M., Martres, M. P., and Schwartz, J.-C., Nature, 253, 362–364 (1975).
Bhargawa, K. P., J. Pharmacol. (Fr.), 5, 73P (1974).
Green, M. D., and Lomax, P., Brain Res. (in the press).
Edvinsson, L., and Owman, Ch., Agents and Actions, 4, 192 (1974).
Tuomisto, L., and Eriksson, L., J. Pharmacol. (Fr.), 5, 101P (1974).
Haas, H. L., Brain Res., 76, 363–366 (1974).
Haas, H. L., Wolf, P., and Nussbaumer, J. C., Brain Res., 88, 166–170 (1975).
Snyder, S. H., and Taylor, K. M., in Perspectives in Neuro-Pharmacology (edit. by Snyder, S. H.), 43–73 (Oxford University Press, New York, 1972).
Phillis, J. W., Tebecis, A. K., and York, D. H., Br. J. Pharmac., 33, 426–440 (1968).
Brimble, M. J., and Wallis, D. I., Nature, 246, 156–158 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HAAS, H., BUCHER, U. Histamine H2-receptors on single central neurones. Nature 255, 634–635 (1975). https://doi.org/10.1038/255634a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/255634a0
This article is cited by
-
Effect of histamine on the hippocampal neurons in guinea-pigs
Agents and Actions (1984)
-
Modulation of low calcium induced field bursts in the hippocampus by monoamines and cholinomimetics
Pfl�gers Archiv European Journal of Physiology (1984)
-
Analysis of histamine actions by intra- and extracellular recording in hippocampal slices of the rat
Agents and Actions (1981)
-
Differences in presynaptic ?-blockade, noradrenaline uptake inhibition, and potential antidepressant activity between (+)- and (-)mianserin
Psychopharmacology (1981)
-
Brain histamine receptors as targets for antidepressant drugs
Nature (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.