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Histamine H2-receptors on single central neurones

Abstract

THE detection of histamine H2-receptor antagonists1,2 has provided fresh impetus to the investigation of central effects of histamine3–7 and its possible role as a neurotransmitter3,8–10. In the hypothalamus of rat and cat microelectrophoretically applied histamine excites a large number of cells. This action, which is unique to the hypothalamus, is not selectively antagonised by the H1-receptor antagonist mepyramine or by the H2-receptor antagonist metiamide8,9. In the cortex of the cat several H1-antagonists were tested but no specific action could be demonstrated11. We report now on a selective antagonism of metiamide against depressant actions of histamine in the cerebral cortex of cat and rat.

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References

  1. Black, J. W., Duncan, W. A. M., Durant, C. J., Ganellin, C. R., and Parsons, E. M., Nature, 236, 385–390 (1972).

    Article  ADS  CAS  Google Scholar 

  2. Black, J. W., Durant, G. J., Emmett, J. C., and Ganellin, C. R., Nature, 248, 65–67 (1974).

    Article  ADS  CAS  Google Scholar 

  3. Baudry, M., Martres, M. P., and Schwartz, J.-C., Nature, 253, 362–364 (1975).

    Article  ADS  CAS  Google Scholar 

  4. Bhargawa, K. P., J. Pharmacol. (Fr.), 5, 73P (1974).

    Google Scholar 

  5. Green, M. D., and Lomax, P., Brain Res. (in the press).

  6. Edvinsson, L., and Owman, Ch., Agents and Actions, 4, 192 (1974).

    Article  CAS  Google Scholar 

  7. Tuomisto, L., and Eriksson, L., J. Pharmacol. (Fr.), 5, 101P (1974).

    Google Scholar 

  8. Haas, H. L., Brain Res., 76, 363–366 (1974).

    Article  CAS  Google Scholar 

  9. Haas, H. L., Wolf, P., and Nussbaumer, J. C., Brain Res., 88, 166–170 (1975).

    Article  CAS  Google Scholar 

  10. Snyder, S. H., and Taylor, K. M., in Perspectives in Neuro-Pharmacology (edit. by Snyder, S. H.), 43–73 (Oxford University Press, New York, 1972).

    Google Scholar 

  11. Phillis, J. W., Tebecis, A. K., and York, D. H., Br. J. Pharmac., 33, 426–440 (1968).

    CAS  Google Scholar 

  12. Brimble, M. J., and Wallis, D. I., Nature, 246, 156–158 (1973).

    Article  ADS  CAS  Google Scholar 

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HAAS, H., BUCHER, U. Histamine H2-receptors on single central neurones. Nature 255, 634–635 (1975). https://doi.org/10.1038/255634a0

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  • DOI: https://doi.org/10.1038/255634a0

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