Abstract
The sympathomimetic amine octopamine (p-hydroxyphenylethanolamine) has the properties of a neurotransmitter in many invertebrate species. In mammals it seems to be a cotransmitter with noradrenaline.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Erspamer, V., and Boretti, G., Archs Int. Pharmacodyn. Ther., 88, 296–332 (1951).
Armstrong, M. D., Shaw, K. N. F., and Wall, P. E., J. biol. Chem., 218, 293–303 (1956).
Kakimoto, Y., and Armstrong, M. D., J. biol. Chem., 237, 422–427 (1962).
Fischer, J., Musacchio, J., Kopin, I. J., and Axelrod, J., Life Sci., 3, 413–419 (1964).
Kopin, I. J., Fischer, J. E., Musacchio, J. M., Horst, W. D., and Weise, V. K., J. Pharmacol. Exp. Ther., 147, 186–193 (1965).
Friedman, S., and Kaufman, S., J. biol. Chem., 240, 552–554 (1965).
Potter, L. T., and Axelrod, J., J. Pharmac. exp. Ther., 142, 291–298 (1963).
Pisano, J. J., Creveling, C. R., and Udenfriend, S., Biochim. biophys. Acta, 43 566–568 (1960).
Molinoff, P. B., Landsberg, L., and Axelrod, J., J. Pharmac. exp. Ther., 179, 253–261 (1969).
Axelrod, J., J. biol. Chem., 237, 1657–1660 (1962).
Harmar, A. J., and Horn, A. S., J. Neurochem, 26, 987–993 (1976).
Saavedra, J. M., Analyt. Biochem., 59, 628–633 (1974).
Saavedra, J. M., Brownstein, M., and Axelrod, J., J. Pharmac. exp. Ther., 186 508–515 (1973).
Coyle, J. T., and Henry, D., J. Neurochem., 21, 61–67 (1973).
Snyder, S. H., Baldessarini, R. J., and Axelrod, J., J. Pharmac. exp. Ther., 153 544–549 (1966).
Saavedra, J. M., and Axelrod, J., J. Pharmac. exp. Ther., 182, 363–369 (1972).
Saavedra, J. M., J. Neurochem., 33, 211–216 (1974).
Tallman, J. F., Saavedra, J. M., Axelrod, J., J. Neurochem., 27, 465–469 (1976).
Molinoff, P. B., and Axelrod, J., Science, 164, 428–429 (1969).
Molinoff, P. B., and Axelrod, J., J. Neurochem., 19, 157–163 (1972).
Saavedra, J. M., Coyle, J. T., and Axelrod, J., J. Neurochem., 23, 511–515 (1974).
Molinoff, P. B., and Buch, S. H. in Trace Amines in the Brain (edit. by Sandler M., and Usdin, E.), 131–160 (Raven, New York, 1976).
Armstrong, M. D., McMillan, A., Shaw, K. N. F., Biochim. biophys. Acta, 25 422–423 (1957).
Brandau, K., and Axelrod, J., Naunyn-Schmiedeberg's Arch. Pharmak., 273 123–133 (1972).
Carlsson, A., and Waldeck, B., Acta pharmac. toxic. 20, 371–374 (1963).
Axelrod, J., Inscoe, J. K., and Daly, J., J. Pharmac. exp. Ther., 149, 16–22 (1965).
Brandau, K., and Axelrod, J., in Frontiers in Catecholamine Research (edit. by Usdin, E., and Snyder, S. H.), 129–131 (Pergamon, New York, 1973).
Jaim-Etchieverry, G., and Zieher, L. M., J. Neurochem., 25, 915–917 (1975).
Baldessarini, R. J., and Vogt, M., J. Neurochem., 19, 755–761 (1972).
Baldessarini, R. J., J. Neurochem., 18, 2509–2518 (1971).
Lands, A. M., and Grant, J. E., J. Pharmac. exp. Ther., 106, 341–345 (1952).
Fischer, J. E., and Baldessarini, R. J., Lancet, ii, 75–80 (1971).
Floyd, K. F., Davidson, L., Gall, D. G., and McCling, H. J., Proc. Fifth Annual Meeting for Society for Neurosciences, 394 (Society of Neuroscience, Bethesda, Md, 1975).
Juorio, A. V., and Molinoff, P. B., J. Neurochem., 22, 271–280 (1974).
Saavedra, J. M., Brownstein, M. J., Carpenter, D. O., and Axelrod, J., Science, 185, 364–365 (1974).
Brownstein, M. J., Saavedra, J. M., Axelrod, J., Zeman, G. H., and Carpenter, D. O., Proc. natn. Acad. Sci. U.S.A., 71, 4662–4665 (1974).
Barker, D. L., Molinoff, P. B., and Kravitz, E. A., Nature new Biol., 236, 61–63 (1972).
Wallace, B. G., Talamo, B. R., Evans, P. D., and Kravitz, E. A., Brain Res., 74, 349–355 (1974).
Evans, P. D., Talamo, B. R., and Kravitz, E. A., Brain Res., 90, 340–347 (1975).
Robertson, H. A., and Steele, J. E., J. Physiol., Lond., 237, 34P–35P (1974).
Hoyle, G., and Barker, D. L., J. exp. Zool., 193, 433–439 (1975).
Robertson, H. A., Experientia, 31, 1006–1008 (1975).
Robertson, H. A., and Carlsson, A. D., J. exp. Zool., 195, 159–164 (1976).
Nathanson, J. A., and Greengard, P., Science, 180, 308–310 (1973).
Robertson, H. A., and Steele, J. E., J. Neurochem., 19, 1603–1606 (1972).
Carlsson, A. D., J. exp. Biol., 49, 195–199 (1968).
Hoyle, G., J. exp. Zool., 193, 425–431 (1975).
Sullivan, R. E., and Barker, D. L., Proc. Fifth Annual meeting of the Society of Neurosciences, 394 (Society of Neuroscience, Bethesda, Md, 1975).
Carpenter, D. O., and Gaubatz, G. L., Nature, 252, 483–485 (1974).
Levitan, I. B., and Barondes, S. H., Proc. natn. Acad. Sci. U.S.A., 71, 1145–1148 (1974).
Levitan, I. B., Madsen, C. J., and Barondes, S. H., J. Neurobiol., 5, 511–525 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Axelrod, J., Saavedra, J. Octopamine. Nature 265, 501–504 (1977). https://doi.org/10.1038/265501a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/265501a0
This article is cited by
-
Eicosanoids and biogenic monoamines modulate the nodulation process and phenoloxidase activity in flesh flies
International Journal of Tropical Insect Science (2024)
-
A sensitive voltammetric sensor for the simultaneous determination of norepinephrine and its co-transmitter octopamine using a biopolymer modified glassy carbon electrode
Ionics (2023)
-
Elusive amines: migraine depends on biochemical abnormalities
Neurological Sciences (2022)
-
The interaction and mechanism of monoterpenes with tyramine receptor (SoTyrR) of rice weevil (Sitophilus oryzae)
SN Applied Sciences (2020)
-
The role of neurotransmitters and neuromodulators in the pathogenesis of cluster headache: a review
Neurological Sciences (2019)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.