Abstract
WHEN frog skeletal muscle fibres are bathed in solutions containing Cs+ and K+ in the ratio 1 : 4,000, a reduction is observed in the size of inward K currents through the resting membrane. This effect is enhanced by an increase in either hyperpolarisation or external Cs+ concentration. It can be predicted from these findings that regenerative changes in membrane potential should be obtainable in fibres, in the presence of Cs+, that are hyperpolarised by means of a current electrode. Such responses are described in the last part of this report. In squid axon and frog node1,2, internal Cs+ produces a voltage-dependent block of the delayed, outward K currents, though the ratio of Cs+ to K+ required for this effect is far greater than that used in the experiments reported here. A closer parallel can be drawn between our findings and those recently reported on the inward K currents in the starfish egg cell3.
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GAY, L., STANFIELD, P. Cs+ causes a voltage-dependent block of inward K currents in resting skeletal muscle fibres. Nature 267, 169–170 (1977). https://doi.org/10.1038/267169a0
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DOI: https://doi.org/10.1038/267169a0
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