Abstract
A large number of structurally diverse drugs with clinical antidepressant properties share the ability to act as potent inhibitors of histamine-sensitive adenylate cyclase in cell-free preparations from mammalian brain. This common biochemical action may represent part of the molecular basis for the antidepressant properties of these compounds.
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Kanof, P., Greengard, P. Brain histamine receptors as targets for antidepressant drugs. Nature 272, 329–333 (1978). https://doi.org/10.1038/272329a0
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DOI: https://doi.org/10.1038/272329a0
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