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Cellular site of opiate dependence

Abstract

Experiments on whole animals, guinea pig isolated ileum, individual neurones in situ and cultured neuroblastoma–glioma hybrid cells indicate that opiate dependence and associated tolerance develop within neurones bearing specific opiate receptors (opiate-sensitive neurones). The essential change appears to be an hypertrophy of the cyclic AMP system, in response to inhibition by opiate of a neuronal adenylate cyclase.

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Collier, H. Cellular site of opiate dependence. Nature 283, 625–629 (1980). https://doi.org/10.1038/283625a0

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