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Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor

Nature volume 339, pages 439–445 (1989)Cite this article

Abstract

The sequence of 5,037 amino acids composing the ryanodine receptor from rabbit skeletal muscle sarcoplasmic reticulum has been deduced by cloning and sequencing the complementary DNA. The predicted structure suggests that the calcium release channel activity resides in the C-terminal region of the receptor molecule, whereas the remaining portion constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum and the transverse tubule.

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Authors and Affiliations

  1. Departments of Medical Chemistry and Molecular Genetics, Faculty of Medicine, Kyoto University, Kyoto, 606, Japan

    Hiroshi Takeshima, Seiichiro Nishimura, Takeshi Matsumoto, Hiroyuki Ishida & Shosaku Numa

  2. Department of Pathology, Institute for Virus Research, Kyoto University, Kyoto, 606, Japan

    Masamichi Ueda & Masao Hanaoka

  3. Department of Biochemistry, Miyazaki Medical College, Miyazaki, 889-16, Japan

    Kenji Kangawa, Naoto Minamino & Hisayuki Matsuo

  4. Pharmaceutical Institute, Keio University School of Medicine, Tokyo, 160, Japan

    Tadaaki Hirose

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  1. Hiroshi Takeshima
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Takeshima, H., Nishimura, S., Matsumoto, T. et al. Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor. Nature 339, 439–445 (1989). https://doi.org/10.1038/339439a0

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