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Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence

Abstract

Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.

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Papazian, D., Timpe, L., Jan, Y. et al. Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature 349, 305–310 (1991). https://doi.org/10.1038/349305a0

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