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Regulated portals of entry into the cell

Nature volume 422, pages 37–44 (2003)Cite this article

Abstract

The plasma membrane is the interface between cells and their harsh environment. Uptake of nutrients and all communication among cells and between cells and their environment occurs through this interface. ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane. It controls entry into the cell and has a crucial role in development, the immune response, neurotransmission, intercellular communication, signal transduction, and cellular and organismal homeostasis. As the complexity of molecular interactions governing endocytosis are revealed, it has become increasingly clear that it is tightly coordinated and coupled with overall cell physiology and thus, must be viewed in a broader context than simple vesicular trafficking.

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Figure 1: Multiple portals of entry into the mammalian cell.
Figure 2: Cargo-stimulated signalling pathways induce uptake by phagocytosis and caveolae.
Figure 3: Core components of the machinery driving clathrin-mediated endocytosis.
Figure 4: Clathrin-mediated endocytosis is accompanied by the temporally and spatially regulated interactions of multiple factors.

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Acknowledgements

We thank R. Milligan, M. G. Finn and C. Waterman-Storer for critically reading the manuscript, and acknowledge the many researchers whose important contributions to the primary literature can be found in the reviews that were cited owing to space limitations.

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  1. Department of Cell Biology, The Scripps Research Institute, La Jolla, California, 92037, USA

    Sean D. Conner & Sandra L. Schmid

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Conner, S., Schmid, S. Regulated portals of entry into the cell. Nature 422, 37–44 (2003). https://doi.org/10.1038/nature01451

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