Abstract
Arising from H. A. Tissenbaum & L. Guarente Nature 410, 227–230 (2001)10.1038/35065638
Tissenbaum and Guarente1 identified the first metazoan Sir2 homologue shown to affect lifespan, Caenorhabditis elegans sir-2.1. Independent transgenic lines harbouring extrachromosomal DNA arrays containing sir-2.1 and the dominant transgene marker rol-6(su1006) were reported to extend mean lifespan between 15% and 50%1. Similar extensions in mean lifespan were also found for lines in which the sir-2.1 transgenic arrays were integrated into the genome following γ-irradiation1. However, the extension of lifespan was overestimated in a high-copy sir-2.1 transgene-containing worm strain because of an unlinked mutation.
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References
Tissenbaum, H. A. & Guarente, L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227–230 (2001)
Apfeld, J. & Kenyon, C. Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804–809 (1999)
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Viswanathan, M., Kim, S. K., Berdichevsky, A. & Guarente, L. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 9, 605–615 (2005)
Berdichevsky, A., Viswanathan, M., Horvitz, H. R. & Guarente, L. C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125, 1165–1177 (2006)
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M.V. and L.P.G. planned experiments. M.V. performed experiments and analysed data.
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Competing financial interests: LG is co-chair of the SAB of Sirtris/GSK.
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Viswanathan, M., Guarente, L. Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature 477, E1–E2 (2011). https://doi.org/10.1038/nature10440
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DOI: https://doi.org/10.1038/nature10440
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