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Secretory trafficking in neuronal dendrites

Nature Cell Biology volume 6, pages 585–591 (2004)Cite this article

Abstract

The neuronal secretory pathway represents the intracellular route for proteins involved in synaptic transmission and plasticity, as well as lipids required for outgrowth and remodelling of dendrites and axons. Although neurons use the same secretory compartments as other eukaryotic cells, the enormous distances involved, as well as the unique morphology of the neuron and its signalling requirements, challenge canonical models of secretory pathway organization. Here, we review evidence for a distributed secretory pathway in neurons, suggest mechanisms that may regulate secretory compartment distribution, and discuss the implications of a distributed secretory pathway for neuronal morphogenesis and neural-circuit plasticity.

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Figure 1: Neurons have an immense and complex plasma membrane.
Figure 2: Secretory pathway components.
Figure 3: ER exit sites are distributed throughout neuronal and non-neuronal cells.
Figure 4: Neurons have both somatic and dendritic Golgi.
Figure 5: Examples of Golgi biogenesis and dispersal.
Figure 6

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Acknowledgements

We thank the reviewers, as well as T. Blanpied, D. Gitler, J. Hernandez, A. Mizrahi, F. Wang, and J. Welch, for critical comments and suggestions. In addition, we apologize to those whose work we did not cite because of space limitations. Work from the laboratory of M.D.E. is supported by the National Institutes of Health (NS39402 and MH64748), the Christopher Reeve Paralysis Foundation, and the Ruth K. Broad Biomedical Research Foundation. A.C.H. is also supported by the Gertrude Elion Award from the Triangle Community Foundation.

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  1. Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, 27710, NC, USA

    April C. Horton

  2. Department of Neurobiology, Department of Cell Biology, Department of Pharmacology and Cancer Biology, and the Neuroproteomics Laboratory, Duke University Medical Center, Box 3209, Durham, 27710, NC, USA

    Michael D. Ehlers

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Horton, A., Ehlers, M. Secretory trafficking in neuronal dendrites. Nat Cell Biol 6, 585–591 (2004). https://doi.org/10.1038/ncb0704-585

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