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Common variants in FOXP1 are associated with generalized vitiligo

Abstract

In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10−8) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10−7).

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Figure 1: Newly replicated associations in generalized vitiligo.

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References

  1. Picardo, M. & Taïeb, A. (eds.) Vitiligo (Springer, Heidelberg & New York, 2010).

  2. Alkhateeb, A. et al. Pigment Cell Res. 16, 208–214 (2003).

    Article  Google Scholar 

  3. Spritz, R.A. The genetics of generalized vitiligo. Curr. Dir. Autoimmun. 10, 244–257 (2008).

    Article  CAS  Google Scholar 

  4. Jin, Y. et al. New Engl. J. Med. 362, 1686–1697 (2010).

    Article  CAS  Google Scholar 

  5. Purcell, S. et al. Am. J. Hum. Genet. 81, 559–575 (2007).

    Article  CAS  Google Scholar 

  6. Horvath, S. et al. Genet. Epidemiol. 26, 61–69 (2004).

    Article  Google Scholar 

  7. The Wellcome Trust Case Control Consortium. Nature 447, 661–678 (2007).

  8. Hu, H. et al. Nat. Immunol. 7, 819–826 (2006).

    Article  CAS  Google Scholar 

  9. Feng, X. et al. Blood 115, 510–518 (2010).

    Article  CAS  Google Scholar 

  10. Shi, C. et al. Blood 112, 4699–4711 (2008).

    Article  CAS  Google Scholar 

  11. Ochs, H.D., Gambineri, E. & Torgerson, T.R. Immunol. Res. 38, 112–121 (2007).

    Article  CAS  Google Scholar 

  12. Salazar-Gonzalez, R.M. et al. Immunity 24, 623–632 (2006).

    Article  CAS  Google Scholar 

  13. Barrett, J.C. et al. Nat. Genet. 40, 955–962 (2008).

    Article  CAS  Google Scholar 

  14. Birlea, S.A., Gowan, K., Fain, P.R. & Spritz, R.A. J. Invest. Dermatol. 130, 798–803 (2010).

    Article  CAS  Google Scholar 

  15. Luo, D.F. et al. Am. J. Hum. Genet. 57, 911–919 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We thank the membership of Vitiligo Support International, the Vitiligo Society, the National Vitiligo Foundation, the American Vitiligo Research Foundation and Associazione Ricerca Informazione per la Vitiligine for their enthusiastic participation. Supported by grants AR45584 and AR056292 from the US National Institutes of Health.

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Authors and Affiliations

Authors

Contributions

Y.J. performed statistical analyses. K.G. managed computer databases and genotype data. S.L.R. and C.M.M. managed DNA samples and contributed to experimental procedures. P.J.H. managed subject coordination. S.A.B., D.C.B., M.R.W., W.T.M., E.H.K., D.J.G., A.P.W., M.P., G.L., A.T., T.J., K.E., N.v.G., J.L. and A.O. provided subject samples and phenotype information. P.R.F. and R.A.S. oversaw and managed all aspects of the study. R.A.S. wrote the first draft of the manuscript. All authors contributed to the final paper.

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Correspondence to Richard A Spritz.

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The authors declare no competing financial interests.

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Jin, Y., Birlea, S., Fain, P. et al. Common variants in FOXP1 are associated with generalized vitiligo. Nat Genet 42, 576–578 (2010). https://doi.org/10.1038/ng.602

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