Abstract
In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10−8) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10−7).
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Acknowledgements
We thank the membership of Vitiligo Support International, the Vitiligo Society, the National Vitiligo Foundation, the American Vitiligo Research Foundation and Associazione Ricerca Informazione per la Vitiligine for their enthusiastic participation. Supported by grants AR45584 and AR056292 from the US National Institutes of Health.
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Y.J. performed statistical analyses. K.G. managed computer databases and genotype data. S.L.R. and C.M.M. managed DNA samples and contributed to experimental procedures. P.J.H. managed subject coordination. S.A.B., D.C.B., M.R.W., W.T.M., E.H.K., D.J.G., A.P.W., M.P., G.L., A.T., T.J., K.E., N.v.G., J.L. and A.O. provided subject samples and phenotype information. P.R.F. and R.A.S. oversaw and managed all aspects of the study. R.A.S. wrote the first draft of the manuscript. All authors contributed to the final paper.
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Jin, Y., Birlea, S., Fain, P. et al. Common variants in FOXP1 are associated with generalized vitiligo. Nat Genet 42, 576–578 (2010). https://doi.org/10.1038/ng.602
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DOI: https://doi.org/10.1038/ng.602
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