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Male fertility is dependent on dipeptidase activity of testis ACE

Nature Medicine volume 11, pages 1140–1142 (2005)Cite this article

To the editor:

Testis angiotensin-converting enzyme (ACE) is an isozyme exclusively expressed by developing sperm1,2. This protein has only a single catalytic domain containing the HEXXH consensus-site motif typical of zinc metallopeptidases3. The exact role of testis ACE is unknown, but male mice lacking the protein reproduce poorly, despite normal numbers of sperm and normal motility4,5,6.

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Figure 1: Creation and analysis of mutant mice.

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Acknowledgements

This work was supported by US National Institutes of Health (NIH) grants DK39777, DK51445 and DK55503 (to K.B.), HD23479 (to B.D.S.), F32 DK065410 (to K.F.) and T32 GM08367 (to R.L.), the National Kidney Foundation (to S.F.) and a Scientist Development Grant from the American Heart Association (to H.D.X.). SPAM1-specific antibody was a gift from P. Martin-De Leon (University of Delaware). The authors also thank P. Selvaraj for constructive discussions.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, 30322, Georgia

    Sebastien Fuchs, Kristen Frenzel, Hong D Xiao, Jonathan W Adams & Kenneth E Bernstein

  2. Institut National de la Sante et de la recherche Medicale, Unite 36, College de France, Paris, 75005, France

    Christine Hubert, Laurent Muller, Annie Michaud & Pierre Corvol

  3. Department of Cell Biology, Emory University School of Medicine, Atlanta, 30322, Georgia

    Robert Lyng & Barry D Shur

  4. Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, 84112, Utah

    Mario R Capecchi

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Fuchs, S., Frenzel, K., Hubert, C. et al. Male fertility is dependent on dipeptidase activity of testis ACE. Nat Med 11, 1140–1142 (2005). https://doi.org/10.1038/nm1105-1140

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