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Cytokines

Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation

Abstract

IL-10 is a potent immunosuppressant which inhibits allo-antigen-specific T cell responses. In addition, IL-10 is a strong endogenous anti-inflammatory cytokine. To investigate the role of IL-10 in the induction of acute GVHD following allogeneic bone marrow transplantation (BMT) we performed a prospective study on spontaneous IL-10 production by peripheral blood mononuclear cells (PBMNC) in 84 patients admitted for allogeneic BMT. High spontaneous IL-10 production by PBMNC at the time of admission and prior to any preparative treatment correlated with a subsequent low incidence of GVHD and transplant-related mortality (8%), as compared to patients with low or intermediate IL-10 production (50%, P < 0.01). Our data demonstrate the prognostic significance of increased IL-10 production in BMT patients and suggest a major role of IL-10 in maintaining immunobalance in the setting of allogeneic BMT. Bone Marrow Transplantation (2000) 25, 237–241.

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Acknowledgements

We wish to acknowledge the help of the nurses of the BMT unit in collection of blood samples. We appreciate the skillful technical assistence of M Albiez, E Rustige, M Schreglmann and M Bigler in performing PBMNC cultures and ELISAs. This work was supported by grants No. Ho1142/1-3/4 and Ei68/2-1 from the Deutsche Forschungsgemeinschaft (DFG).

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Holler, E., Roncarolo, M., Hintermeier-Knabe, R. et al. Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation. Bone Marrow Transplant 25, 237–241 (2000). https://doi.org/10.1038/sj.bmt.1702126

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