Abstract
All trans retinoic acid (ATRA) is able to induce complete remission (CR) in almost all patients with acute promyelocytic leukemia (APL) through in vivo differentiation of APL blasts. However, it cannot eliminate the leukemic clone and to be effective must be used in combination with anthracycline-based chemotherapy. Experience accumulated over the last 10 years has clearly shown that the combination of ATRA and chemotherapy gives better survival in newly diagnosed APL than chemotherapy alone because of fewer relapses and a higher CR rate experienced by these patients. It is also strongly suggested that maintenance treatment with ATRA, and possibly in combination with low-dose chemotherapy, can further reduce the incidence of relapse. Overall, more than 90% of patients with newly diagnosed APL can achieve CR and about 75% can be cured by the combination of ATRA and chemotherapy.
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Abbreviations
- APL:
-
acute promyelocytic leukemia
- ATRA:
-
all trans retinoic acid
References
Arnould C, Philippe C, Bourdon V, Gregoire MJ, Berger R, Jonveaux P . 1999 Hum. Mol. Genet. 8: 1741–1749
Avvisati G, Mele A, Stazi MA, Vegna ML, Pasquini P, Mandelli F . 1991 Ann. Oncol. 2: 405–408
Avvisati G, Ten Cate JW, Mandelli F . 1990 The coagulopathy in APL: DIC? Muszbek L (ed): Hemostasis and Cancer Boca Raton, FL, CRC pp. 91–100
Avvisati G . 1999 Blood 94: suppl.1, abst 505a
Beaumont M, Laï JL, Simonnet E, Preudhomme E, Plantier I, Quesnel B, Bauters F, Fenaux P . 2000 Blood 96: 321a
Bennett JM, Catowsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C . 1976 Br. J. Haematol. 33: 451–458
Bennett JM, Catowsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C . 1980 Ann. Intern. Med. 92: 261–262
Bernard J, Weil M, Boiron M, Jacquillat C, Flandrin G, Gemon MF . 1973 Blood 41: 489–496
Bernard J, Mathé G, Boulay J . 1959 Schweiz Med. Wochenschr. 89: 604–608
Biondi A, Rambaldi A, Pandolfi PP, Rossi V, Giudici G, Alcalay M, Lococo F, Diverio D, Pogliani EM, Lanzi EM . 1992 Blood 80: 492–497
Breitman TR, Collins AJ, Keene BR . 1981 Blood 57: 1000–1008
Caen J, Larrieu MH, Bernard J . 1959 Rev. Fr. Et. Clin. Biol. 4: 363–366
Caen J, Mathé G, Lexman C, Bernard J . 1957 Etude de la fibrinolyse au cours des hémopathies malignes Cong. Eur. Hemat. Karger Eds pp. 502–506
Cassinat B, Chomienne C . 2001 Seminars in Hematology. L. Degos (ed) WB Saunders: Philadelphia USA
Castaigne S, Balitrand N, de The H, Dejean A, Degos L, Chomienne C . 1992 Blood 79: 3110–3118
Castaigne S, Chomienne C, Daniel MT, Ballerini P, Berger R, Fenaux P, Degos L . 1990 Blood 76: 1704–1713
Chen ZC, Brand NJ, Chen A, Chen SJ, Tong SH, Wang ZY, Waxman S, Zelent A . 1993 EMBO J. 12: 1161–1167
Chomienne C, Balitrand N, Abita JP . 1986 Leuk. Res. 10: 1079–1081
Chomienne C, Balitrand N, Cost H, Dagos L, Abita JP . 1986 Leuk. Res. 10: 1301–1305
Chomienne C, Ballerini P, Balitrand N, Daniel MT, Fenaux P, Castaigne S, Degos L . 1990 Blood 76: 1710–1719
Cornic M, Delva L, Guidez F, Balitrand N, Degos L, Chomienne C . 1992 Cancer Res. 52: 3329–3334
Dombret H, Scrobohaci ML, Daniel MT, Miclea JM, Castaigne S, Chomienne C, Fenaux P, Degos L . 1995 Leukemia 9: 19–24
Douer D, Preston-Martin S, Chang E, Nichols DW, Watkins KJ, Levine AM . 1996 Blood 87: 308–313
Dubois C, Schlageter MH, de Gentile A, Balitrand N, Toubert ME, Krawice I, Fenaux P, Castaigne S, Najean Y, Degos L . 1994 Leukemia 8: 1750–1757
Fenaux P, Castaigne S, Dombret H, Archimbaud E, Duarte M, Morel P, Lamy T, Tilly H, Guerci A, Maloisel F . 1992 Blood 80: 2176–2181
Fenaux P, Chastang C, Chevret S, Sanz M, Dombret H, Archimbaud E, Fey M, Rayon C, Huguet F, Sotto JJ, Gardin C, Cony-Hakhoul P, Travade P, Solary E, Fegueux N, Bordessoule D, San Miguel J, Link H, Desablens B, Stamatoullas A, Deconinck E, Maloisel F, Castaigne S, Preudhomme C, Degos L . 1999 Blood 94: 1192–1200
Fenaux P, Chevret S, Guerci A, Fegueux N, Dombret H, Thomas X, Sanz M, Link H, Maloisel F, Gardin C, Bordessoule D, Stoppa AM, Saddoun A, Muus P, Wandt H, Mineur P, Wittaker JA, Fey M, Daniel MT, Castaigne S, Degos L . 2000 Leukemia 14: 1371–1377
Fenaux P, Le Deley MC, Castaigne S, Archimbaud E, Chomienne C, Link H, Duarte M, Daniel MT, Bowero D . 1993 Blood 82: 3241–3249
Ferrara F, Morabito F, Martino B, Specchia G, Liso V, Nobile F, Boccuni P, Di Noto R, Pane F, Annunziata M, Schiavone EM, de Simone M, Guglielmi C, Del Vecchio L, Lo Coco F . 2000 J. Clin. Oncol. 18: 1295–1300
Frankel SR, Eardley A, Lauwers G, Weiss M, Warrell RP . 1992 Ann. Intern. Med. 117: 293–296
Golomb HM, Rowley J, Vardiman J, Baron J, Locker G, Krasnow S . 1976 Arch. Intern. Med. 136: 825–828
Guglielmi C, Martelli MP, Diverio D, Feno S, Vegia ML, Cante Rasnoldi M, Biondi A, Cocito MG, Del Vecchio L, Tabilio A, Avvisati G, Basso G, Lo Coco F . 1998 Br. J. Haematol. 102: 1035–1041
Hillestad LK . 1957 Acta. Med. Scand. 159: 189–194
Huang M, Yu-Chen Y, Shu-Rong C, Chai JR, Lu JX, Zhoa L, Go LJ, Wang ZY . 1988 Blood 72: 567–578
Huang W, Sun GL, Li XS, Cao Q, Lu Y, Jang GZ, Zhang FQ, Chai JR, Wang ZY, Waxman S . 1993 Blood 82: 1264–1269
Jansen JH, de Ridder MC, Geertsma WM, Eperlink CAJ, Van Lom K, Smit EHE, Slater R, Reigden B, de Greef GE, Sonneveld P, Lowenberg B . 1999 Blood 94: 39–45
Kanamaru A, Takemoto Y, Tanimoto M, Murakami H, Asou N, Kobayashi T, Ohmoto E, Sakamaki H, Tsubaki K . 1995 Blood 85: 1202–1206
Larson RA, Kondo K, Vardiman JW, Butler AE, Golomb HM, Rowley JD . 1984 Am. J. Med. 76: 827–841
Lo Coco F, Diverio D, Avvisati G, Petti MC, Meloni G, Pogliani E, Biondi A, Rossi G, Carlostella C, Selleri C, Martino B, Specchia G, Mandelli F . 1999 Blood 94: 2225–2229
Menell JS, Cesarman GM, Jacovina A, McLaughlin MA, Lev EA, Hajjar KA . 1999 N. Engl. J. Med. 340: 994–1004
Micléa JM, Chomienne C . 1994 Leukemia 8: 214–215
Muindi J, Frankel SR, Miller WH, Jakubowski A, Scheinberg DA, Young CW . 1992 Blood 79: 299–303
Murray CK, Estey E, Paietta E, Howard RS, Edenfield WJ, Pierce S, Mann KP, Bolan C, Byrd JC . 1999 J. Clin. Onco. 17: 293–297
Redner RL, Rush EA, Faas S, Rudert WA, Corey SJ . 1996 Blood 87: 882–886
Rodeghiero F, Avvisati G, Castaman G, Barbui T, Mandellui F . 1990 Blood 75: 2112–2117
Rowley JD, Golomb HM, Dougherty C . 1977 Lancet i: 549–550
Schoch C, Haase D, Haferlach T, Freund M, Link H, Lengfelder E, Loffler H, Buchner T, Fonatsch C . 1996 Br. J. Haematol. 94: 493–500
Slack JL, Arthur DC, Lawrence D, Mrozek K, Mayer RJ, Davey FR, Tantravahi R, Pettanati MJ, Bigner S, Caroll AJ, Rao KW, Schiffer CA, Bloomfield CD . 1997 J. Clin. Oncol. 15: 1786–1795
Tallman MS, Andersenn JW, Schiffer CA, Appelbaum FR, Feusner JH, Ogden A, Shepherd L, Willman C, Bloomfield CD, Rowe JM, Wiernik PH . 1997 N. Engl. J. Med. 337: 1021–1028
Vahdat L, Maslak P, Miller WH, Eardley A, Heller G, Scheinberg DA, Warrell RP . 1994 Blood 84: 3843–3849
Wang ZY, Sun GL, Shen ZX . 1999 Chin. MJ. 112: 963–967
Warrell RP, Maslak P, Eardley A, Heller G, Miller WH, Frankel SR . 1994 Leukemia 8: 929–933
Warrell RP, Frankel SR, Miller W, Scheinberg DA, Hri LM, Hittelman WN, Vyas R, Andreeff M, Tafuri A, Jakubowski A . 1991 N. Engl. J. Med. 324: 1385–1393
Wells RA, Catzavelos C, Kamel-Reid S . 1997 Nat. Genet. 17: 109–113
Zhu J, Guo WM, Yao YY, Zhao WL, Pan L, Cai X, Ju B, Sun GL, Wang HL, Chen SJ, Chen GQ, Caen J, Chen Z, Wang ZY . 1999 Leukemia 13: 1062–1070
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Degos, L., Wang, Z. All trans retinoic acid in acute promyelocytic leukemia. Oncogene 20, 7140–7145 (2001). https://doi.org/10.1038/sj.onc.1204763
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