Issue 9, 2010

Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs

Abstract

The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(III)-catalyzed aza-Diels–Alder cyclization. Optimization of solvent and reaction temperature provided enhanced endo-diastereoselectivity.

Graphical abstract: Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs

Supplementary files

Article information

Article type
Paper
Submitted
20 Jan 2010
Accepted
25 Feb 2010
First published
16 Mar 2010

Org. Biomol. Chem., 2010,8, 2252-2259

Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs

R. Burai, C. Ramesh, M. Shorty, R. Curpan, C. Bologa, L. A. Sklar, T. Oprea, E. R. Prossnitz and J. B. Arterburn, Org. Biomol. Chem., 2010, 8, 2252 DOI: 10.1039/C001307B

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