Section 1: Perinatal Programming of Chronic Kidney Disease
Intrauterine Growth Restriction: Fetal Programming of Hypertension and Kidney Disease

https://doi.org/10.1053/j.ackd.2008.01.001Get rights and content

The etiology of hypertension historically includes 2 components: genetics and lifestyle. However, recent epidemiologic studies report an inverse relationship between birth weight and hypertension suggesting that a suboptimal fetal environment may also contribute to increased disease in later life. Experimental studies support this observation and indicate that cardiovascular/kidney disease originates in response to fetal adaptations to adverse conditions during prenatal life.

Index Words

Fetal programming
Hypertension
Kidney
Experimental models

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Barbara T. Alexander is supported by NIH grants HL074927 and HL51971.

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