Characterization of PGE2 receptors in fetal and newborn ductus arteriosus in the pig2
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Transcriptional profiling of the ductus arteriosus: Comparison of rodent microarrays and human RNA sequencing
2018, Seminars in PerinatologyCitation Excerpt :EP4 is a G-protein coupled receptor and primary regulator of DA patency. EP4 is the predominant prostanoid receptor in the mammalian DA.46–54 During late gestation, circulating prostaglandin E2 (PGE2) stimulates EP4 to maintain DA patency.48–50
Effect of PGE2 on DA tone by EP4 modulating Kv channels with different oxygen tension between preterm and term
2011, International Journal of CardiologyCitation Excerpt :Hence, it was demonstrated that the responses of term DAs to reduced-PGE2 induced contraction became stronger and stronger with time elapsing after birth (Fig. 1:A,B-4), at equal pace with Kv expression(Fig. 2: B). Therefore, the urgent constriction of term DA comes from PO2 increase as stated in another study [22], but its further constriction mainly mediated by reduced-PGE2 and Kv expression decrease. This induction also agrees with the ELISA result of PGE2 in our former studies that blood PGE2 didn't reduce significantly until 2 h later after birth (data not shown).
A novel role for PGE<inf>2</inf>-EP<inf>4</inf> in the developmental programming of the mouse ductus arteriosus: consequences for vessel maturation and function
2023, American Journal of Physiology - Heart and Circulatory PhysiologyProstaglandin E-mediated molecular mechanisms driving remodeling of the ductus arteriosus
2015, Pediatrics InternationalThe prostanoid EP4 receptor and its signaling pathway
2013, Pharmacological Reviews
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This study was supported by Grants from the Medical Research Council of Canada, Heart & Stroke Foundation of Quebec and Fonds de la Recherche en Santé du Québec, and from U.S. Public Health Service, National Institutes of Health (NIH), NHLBI HL46691.