Cyclosporine-A treatment inhibits the expression of metabotropic glutamate receptors in rat thymus
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Cited by (30)
Glutamate in peripheral organs: Biology and pharmacology
2016, European Journal of PharmacologyCitation Excerpt :Considering the significant protective role of glutamate in gastric ulcer caused by multiple factors, it has potential as a therapy agent in gastrointestinal injury. Real-time polymerase chain reaction (RT-PCR), western blotting and flow cytometry have revealed the expression of glutamate receptors and transporters in T cells and B cells, as well as in dendritic cells (Rezzani et al., 2003) and macrophages (Dickman et al., 2004a, 2004b), which suggests a role of glutamate both in the innate immune system and adoptive immune systems (Boldyrev et al., 2005). For example, in normal human T cells, AMPA receptor and mGlu3 receptor are definitely expressed.
Stimulation of N-methyl-d-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin
2007, Biochemical and Biophysical Research CommunicationsMetabotropic glutamate receptors: Beyond the regulation of synaptic transmission
2007, PsychoneuroendocrinologyCitation Excerpt :Interestingly, mGlu1 receptors were found in immature CD4−/CD8− thymocytes, whereas expression of mGlu5 receptors was restricted to the more mature CD4+/CD8+ and CD4+/CD8− thymocytes (Storto et al., 2000). The existence of mGlu receptors in the thymus has been confirmed by Rezzani et al. (2003), who have found that (i) mGlu2/3, mGlu4, and mGlu5 receptors are widely expressed in thymic cells; (ii) mGlu5 receptors are preferentially expressed in thymic medullary cells; and (iii) a 2-day treatment with the immunosuppressant, cyclosporin-A, inhibits the expression of all mGlu receptor subtypes in the thymus. A role for mGlu receptors in the activation and function of lymphocytes is emerging from a series of studies that focus on group I and group III mGlu receptors.
Role of glutamate on T-cell mediated immunity
2007, Journal of NeuroimmunologyStimulation of group I metabotropic glutamate receptors evokes calcium signals and c-jun and c-fos gene expression in human T cells
2005, Biochemical PharmacologyCitation Excerpt :In non-neuronal peripheral tissues, the existence of a glutamate-mediated transmission has been demonstrated in several systems [5,6], including immune system. Here specific high affinity l-glutamate binding sites are found on the surface of human T cells [7], while the expression of both iGlu and mGlu receptors is demonstrated in cells of the T lineage (thymocytes and lymphocytes) [8–12]. Through these receptors l-glutamate modulates lymphocyte functions: (i) it potentiates T cell responses ([Ca2+]i rise) to specific stimuli [anti-CD3 monoclonal antibodies (mAb) and phytohemagglutinin (PHA)] by acting on NMDA and non-NMDA iGlu receptors [13]; (ii) it increases lymphocyte adhesion to extracellular matrix proteins and cell motility by acting on AMPA iGlu receptors [10]; (iii) it induces reactive oxygen species formation by acting on NMDA iGlu receptors [12,14].
Inhibition of the functional expression of N-methyl-D-aspartate receptors in a stably transformed cell line by cyclosporin A
2004, Biochemical PharmacologyCitation Excerpt :We could show that cell surface expression of NRs is decreased by treatment with cyclosporin A. A similar influence of CsA was found in rat thymus, where expression of metabotropic glutamate receptors was inhibited by CsA [34]. Although we observed a participitation of the PTP inhibition after short incubation with CsA as observed by others [32], our results clearly indicate, that prolonged treatment with CsA at micromolar concentrations decreases the amount of membrane associated NR protein by a posttranscriptional mechanism which seems to be responsible for the strong protective effect of CsA observed at longer time points.