Journal of the American Academy of Child & Adolescent Psychiatry
ARTICLESBrain Maturation and Subtypes of Conduct Disorder: Interactive Effects on P300 Amplitude and Topography in Male Adolescents
Section snippets
METHOD
All procedures and documents associated with this research had undergone prior review and approval by the University of Connecticut Health Center's Institutional Review Board. The research was conducted in compliance with the ethical standards described within the Helsinki Declaration and the Belmont Report.
Background Characteristics
The first stage in the analysis was an examination of the background demographic, alcohol use, and family history characteristics of the study groups. Tests of group equivalence on continuous measures were performed using 2 (severity) by 2 (age) ANOVAs. Group equivalence on categorical measures was determined by Pearson χ2 tests. The results of these analyses are presented in Table 1.
As can be seen in Table 1, the prevalence of paternal alcohol, cocaine, and heroin dependence was approximately
DISCUSSION
One goal of this study was to determine whether the relationship reported previously (Bauer and Hesselbrock, 1999a) between P300, conduct problems, and brain maturation would generalize to an auditory task that placed high demands on response regulation. This goal was met. Adolescents with conduct problems exhibited a dampened, and almost absent, change in P300 amplitude as a function of age.
The second goal—that is, to demonstrate neurophysiological differences among the subtypes of CD—was also
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2012, Drug and Alcohol DependenceCitation Excerpt :A major growth in risk, corresponding to a shift of the population liability distribution to the right, occurs during the peripubertal period and is strongly associated with disruptive behavior disorders. This association has been theorized by us and others to result from the common mechanisms related to deviations in neurologic maturation (Bauer and Hesselbrock, 2003; Mezzacappa et al., 1999; Tarter et al., 1999). The structure of genetic correlations between liability to addiction and other behavioral traits indicates that sources of CLA are also likely to be unrelated to specific drug action as such, including a specific role of a drug designated as a “gateway”.
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This research was supported in part by Public Health Service grants R01DA08598, R01DA05826, P50AA03510, and R01MH61346.