1932

Abstract

The NOD-like receptors (NLRs) are a specialized group of intracellular receptors that represent a key component of the host innate immune system. Since the discovery of the first NLR almost 10 years ago, the study of this special class of microbial sensors has burgeoned; consequently, a better understanding of the mechanism by which these receptors recognize microbes and other danger signals and of how they activate inflammatory signaling pathways has emerged. Moreover, in addition to their primary role in host defense against invading pathogens, their ability to regulate nuclear factor–kappa B (NF-κB) signaling, interleukin-1-beta (IL-1β) production, and cell death indicates that they are crucial to the pathogenesis of a variety of inflammatory human diseases.

Keyword(s): caspase-1Crohn's diseaseIL-1NLRP3NOD2
Loading

Article metrics loading...

/content/journals/10.1146/annurev.pathol.4.110807.092239
2009-02-28
2024-03-29
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.pathol.4.110807.092239
Loading
/content/journals/10.1146/annurev.pathol.4.110807.092239
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error