Novel Neuronal Nitric Oxide Synthase (nNOS) Selective Inhibitor, Aplysinopsin-Type Indole Alkaloid, from Marine Sponge Hyrtios erecta

Shunji AOKI; Ying YE; Kouichi HIGUCHI; Akira TAKASHIMA; Yoshimi TANAKA; Isao KITAGAWA; Motomasa KOBAYASHI

doi:10.1248/cpb.49.1372

Notes

Novel Neuronal Nitric Oxide Synthase (nNOS) Selective Inhibitor, Aplysinopsin-Type Indole Alkaloid, from Marine Sponge Hyrtios erecta

Shunji AOKI, Ying YE, Kouichi HIGUCHI, Akira TAKASHIMA, Yoshimi TANAKA, Isao KITAGAWA, Motomasa KOBAYASHI

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Keywords: nitric oxide synthase, indole alkaloid, marine sponge

JOURNAL FREE ACCESS

2001 Volume 49 Issue 10 Pages 1372-1374

DOI https://doi.org/10.1248/cpb.49.1372

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Abstract

Two novel aplysinopsin-type indole alkaloids, 1 and 2, and three known indole alkaloids were isolated from the marine sponge Hyrtios erecta. These compounds exhibited selective inhibitory activity against the neuronal isozyme of nitric oxide synthase (nNOS). Furthermore, new quinolone 7 was also isolated from the same marine sponge. The chemical structures of these new compounds were elucidated on the basis of spectroscopic analysis.

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