Chest
Clinical InvestigationsTechniquesExhaled Carbon Monoxide and Nitric Oxide in COPD
Section snippets
Study Subjects
The following four groups of subjects were studied: 10 healthy nonsmokers; 12 healthy smokers; 15 patients with COPD who were ex-smokers; and 15 patients with COPD who were current smokers (Table 1). Patients with COPD attended the outpatient clinic at the Royal Brompton Hospital in London. Informed consent was obtained from all subjects. This study was approved by the Ethics Committee of the Royal Brompton Hospital and Harefield Trust. Study groups were matched for age (Table 1). The diagnosis
Results
The clinical data for healthy subjects and patients with COPD are summarized in Table 1.
Discussion
Oxidative stress is a major component of airway inflammation in patients with COPD.1 In this study, we have suggested a potential new noninvasive method to monitor airway inflammation and oxidative stress in stable ex-smokers with COPD that is based on exhaled NO and CO measurements. Since the levels of exhaled CO and NO are strongly affected by cigarette smoking, their usefulness in current smokers is limited. We found a 2.5-fold increase in the level of exhaled CO in ex-smokers with COPD
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Dr. Montuschi was the recipient of Research Fellowship from the National Research Council of Italy.