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The diverse effects of mast cell mediators

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Conclusions

Interest in MCs is usually aimed at understanding their role in pathological states they are known to be involved in, including allergic diseases (rhinitis, asthma) and chronic inflammatory diseases (Chrohn's disease, systemic sclerosis). Mast cell mediators are usually looked upon in the same manner, focusing on their role in the disease process. Thus, MCs and the mediators they release are seen primarily as producing negative effects, and are not recognized as an integral and necessary part of the innate immune response. Many studies have exemplified the importance of MCs to the proper functioning of the immune system. Mast cell-deficient mice have shown that MCs are necessary for clearance of bacterial infections, and MCs have long been recognized as critical for the removal of parasitic organisms (99–101). Mast cells are also important in fibrosis, which is necessary when tissues are damaged beyond their capability to regenerate. The broad distribution of MCs and their placement close to the external environment makes them critical in the initial response to injury and invading organisms, and their heterogeneity allows them to respond in a manner that is most useful for their anatomical location. *** DIRECT SUPPORT *** A09Q2013 00005

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Hines, C. The diverse effects of mast cell mediators. Clinic Rev Allerg Immunol 22, 149–160 (2002). https://doi.org/10.1385/CRIAI:22:2:149

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