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Mesenchymal Stem Cells in Cancer: Tumor-Associated Fibroblasts and Cell-Based Delivery Vehicles

  • Progress in Hematology
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Abstract

Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anti-cancer agents that blunt tumor growth kinetics and inhibit the growth of tumors in situ. In this review article, we describe the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.

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Authors and Affiliations

  1. Department of Pediatrics, The Ohio State University and Center for Childhood Cancer, Columbus Children’s Research Institute, Columbus, Ohio, USA

    Brett Hall & A. Kate Sasser

  2. Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA

    Jennifer Dembinski, Matus Studeny, Michael Andreeff & Frank Marini

Authors
  1. Brett Hall
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  2. Jennifer Dembinski
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  3. A. Kate Sasser
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  4. Matus Studeny
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  5. Michael Andreeff
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  6. Frank Marini
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Correspondence to Frank Marini.

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Hall, B., Dembinski, J., Sasser, A.K. et al. Mesenchymal Stem Cells in Cancer: Tumor-Associated Fibroblasts and Cell-Based Delivery Vehicles. Int J Hematol 86, 8–16 (2007). https://doi.org/10.1532/IJH97.06230

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  • DOI: https://doi.org/10.1532/IJH97.06230

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