Abstract
Retinoids have shown beneficial therapeutic effects in pre-clinical and animal models for multiple pathologic indications, however severe adverse effects, restricting dosage and efficacy of oral formulations limit their use in patients. The focus of this review includes the actual medicinal use of retinoids and chemical efforts to generate highly selective and less toxic synthetic retinoids.
Keywords: rar, rxr, transcription factors, cancer, skin, type II diabetes, retinoids, rexinoids
Mini-Reviews in Medicinal Chemistry
Title: Retinoids as Therapeutic Agents: Today and Tomorrow
Volume: 5 Issue: 8
Author(s): Valerie Vivat-Hannah and F. Christopher Zusi
Affiliation:
Keywords: rar, rxr, transcription factors, cancer, skin, type II diabetes, retinoids, rexinoids
Abstract: Retinoids have shown beneficial therapeutic effects in pre-clinical and animal models for multiple pathologic indications, however severe adverse effects, restricting dosage and efficacy of oral formulations limit their use in patients. The focus of this review includes the actual medicinal use of retinoids and chemical efforts to generate highly selective and less toxic synthetic retinoids.
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Cite this article as:
Vivat-Hannah Valerie and Zusi Christopher F., Retinoids as Therapeutic Agents: Today and Tomorrow, Mini-Reviews in Medicinal Chemistry 2005; 5 (8) . https://dx.doi.org/10.2174/1389557054553820
DOI https://dx.doi.org/10.2174/1389557054553820 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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