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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Retinoids as Therapeutic Agents: Today and Tomorrow

Author(s): Valerie Vivat-Hannah and F. Christopher Zusi

Volume 5, Issue 8, 2005

Page: [755 - 760] Pages: 6

DOI: 10.2174/1389557054553820

Price: $65

Abstract

Retinoids have shown beneficial therapeutic effects in pre-clinical and animal models for multiple pathologic indications, however severe adverse effects, restricting dosage and efficacy of oral formulations limit their use in patients. The focus of this review includes the actual medicinal use of retinoids and chemical efforts to generate highly selective and less toxic synthetic retinoids.

Keywords: rar, rxr, transcription factors, cancer, skin, type II diabetes, retinoids, rexinoids


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