The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
YM-254890, a Novel Platelet Aggregation Inhibitor Produced by Chromobacterium sp. QS3666
MASATOSHI TANIGUCHI, KOJI NAGAI, NAKAKO ARAO, TOMIHISA KAWASAKI, TETSU SAITO, YUMIKO MORITANI, JUN TAKASAKI, KAZUMI HAYASHI, SHIGEO FUJITA, KEN-ICHI SUZUKI, SHIN-ICHI TSUKAMOTO
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2003 Volume 56 Issue 4 Pages 358-363

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Abstract

A novel platelet aggregation inhibitor, YM-254890, was isolated from the culture broth of strain QS3666. This strain was isolated from a soil sample collected at Okutama, Tokyo, Japan, and was identified as Chromobacterium sp. by morphological and physiological criteria. YM-254890 was purified from the culture supernatant by solvent extraction, ODS and silica gel flash chromatography, followed by preparative HPLC. YM-254890 inhibited ADP-induced platelet aggregation in human platelet-rich plasma with an IC50 value below 0.6μM by blocking the P2Y1 receptor-signal transduction pathway.

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The Journal of Antibiotics, Series A

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