Abstract
E-cadherin-mediated cell-cell adhesion is lost during the development of most epithelial cancers. Recent evidence indicates that the loss of E-cadherin function, besides causing loss of cell-cell adhesion, might also convey signals that actively induce tumour-cell invasion and metastasis.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Cadherins / genetics*
-
Cadherins / physiology
-
Cell Adhesion / genetics
-
Genes, Tumor Suppressor*
-
Homeostasis
-
Humans
-
Neoplasm Invasiveness
-
Neoplasms / etiology
-
Neoplasms / genetics
-
Neoplasms / physiopathology
-
Signal Transduction