A CaMKII inhibitor, KN-62, facilitates DHPG-induced LTD in the CA1 region of the hippocampus

Neuropharmacology. 1999 Apr;38(4):605-8. doi: 10.1016/s0028-3908(98)00229-9.

Abstract

We have shown previously that activation of mGlu receptors using a group I specific mGlu receptor agonist, (R,S)-3,5-dihydroxyphenylglycine (DHPG), can induce long-term depression (LTD) in the CA1 region of the hippocampus (Palmer et al., 1997). We now report that DHPG-induced LTD is facilitated by treatment with KN-62, an inhibitor of certain Ca2+/calmodulin-dependent protein kinases (CaMKs), including CaMKII.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / analogs & derivatives*
  • 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / pharmacology
  • Animals
  • Benzoates / pharmacology
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors*
  • Depression, Chemical
  • Enzyme Inhibitors / pharmacology*
  • Excitatory Amino Acid Antagonists / pharmacology
  • Female
  • Glycine / analogs & derivatives
  • Glycine / pharmacology
  • Hippocampus / drug effects*
  • In Vitro Techniques
  • Methoxyhydroxyphenylglycol / analogs & derivatives*
  • Methoxyhydroxyphenylglycol / pharmacology
  • Neuronal Plasticity / drug effects*
  • Rats
  • Rats, Wistar
  • Signal Transduction / drug effects
  • Synaptic Transmission / drug effects

Substances

  • Benzoates
  • Enzyme Inhibitors
  • Excitatory Amino Acid Antagonists
  • alpha-methyl-4-carboxyphenylglycine
  • Methoxyhydroxyphenylglycol
  • KN 62
  • 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Glycine
  • 3,4-dihydroxyphenylglycol