Abstract
We have shown previously that activation of mGlu receptors using a group I specific mGlu receptor agonist, (R,S)-3,5-dihydroxyphenylglycine (DHPG), can induce long-term depression (LTD) in the CA1 region of the hippocampus (Palmer et al., 1997). We now report that DHPG-induced LTD is facilitated by treatment with KN-62, an inhibitor of certain Ca2+/calmodulin-dependent protein kinases (CaMKs), including CaMKII.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / analogs & derivatives*
-
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / pharmacology
-
Animals
-
Benzoates / pharmacology
-
Calcium-Calmodulin-Dependent Protein Kinase Type 2
-
Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors*
-
Depression, Chemical
-
Enzyme Inhibitors / pharmacology*
-
Excitatory Amino Acid Antagonists / pharmacology
-
Female
-
Glycine / analogs & derivatives
-
Glycine / pharmacology
-
Hippocampus / drug effects*
-
In Vitro Techniques
-
Methoxyhydroxyphenylglycol / analogs & derivatives*
-
Methoxyhydroxyphenylglycol / pharmacology
-
Neuronal Plasticity / drug effects*
-
Rats
-
Rats, Wistar
-
Signal Transduction / drug effects
-
Synaptic Transmission / drug effects
Substances
-
Benzoates
-
Enzyme Inhibitors
-
Excitatory Amino Acid Antagonists
-
alpha-methyl-4-carboxyphenylglycine
-
Methoxyhydroxyphenylglycol
-
KN 62
-
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
-
Calcium-Calmodulin-Dependent Protein Kinase Type 2
-
Calcium-Calmodulin-Dependent Protein Kinases
-
Glycine
-
3,4-dihydroxyphenylglycol