Abstract
During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-Cgamma1-Ca2+ signalling pathways. TCR-induced cytoskeletal changes involve signalling through SLP-76-Vav-Nck to activate effectors of the Rho-family of GTPases. Finally, glycolipid-enriched microdomains play a crucial role in T cell activation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing*
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Animals
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Calcium / metabolism
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Carrier Proteins / metabolism
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Cytoskeleton / metabolism
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Humans
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Isoenzymes / metabolism
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Membrane Proteins*
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Phospholipase C gamma
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Phosphoproteins / metabolism
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Phosphorylation
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Protein-Tyrosine Kinases / metabolism
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-cbl
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Receptors, Antigen, T-Cell / physiology*
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Signal Transduction / immunology*
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Signal Transduction / physiology
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Type C Phospholipases / metabolism
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Ubiquitin-Protein Ligases*
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ras Proteins / metabolism
Substances
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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Isoenzymes
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LAT protein, human
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Membrane Proteins
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Phosphoproteins
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Proto-Oncogene Proteins
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Receptors, Antigen, T-Cell
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SLP-76 signal Transducing adaptor proteins
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Proto-Oncogene Proteins c-cbl
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Ubiquitin-Protein Ligases
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Protein-Tyrosine Kinases
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Type C Phospholipases
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Phospholipase C gamma
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ras Proteins
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CBL protein, human
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Calcium