Abstract
The elevation of intracellular calcium is a major effector of stimulus-induced physiological change in a variety of cell types. Such change is invariably complex and frequently involves the activation of gene expression. Calcium signals are often able to activate different subsets of genes within the same cell, the basis for which has been unclear. Recent studies have revealed that a number of differing properties of the calcium signal are responsible for distinct cellular responses.
Copyright 1999 Wiley-Liss, Inc.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcium / physiology*
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Calcium Signaling
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Calcium-Calmodulin-Dependent Protein Kinases / physiology
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Cell Nucleus / metabolism
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Cyclic AMP Response Element-Binding Protein / physiology
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Cytoplasm / metabolism
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Gene Expression Regulation*
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Humans
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Response Elements
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Second Messenger Systems / physiology*
Substances
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Cyclic AMP Response Element-Binding Protein
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Calcium-Calmodulin-Dependent Protein Kinases
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Calcium