Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3

Biochim Biophys Acta. 1999 Oct 28;1447(2-3):307-12. doi: 10.1016/s0167-4781(99)00167-0.

Abstract

GABA(C) receptors mediate rapid inhibitory neurotransmission in retina. We have mapped, in detail, the human genes which encode the three polypeptides that comprise this receptor: rho1 (GABRR1), rho2 (GABRR2) and rho3 (GABRR3). We show that GABRR1 and GABRR2 are located close together, in a region of chromosome 6q that contains loci for inherited disorders of the eye, but that GABRR3 maps to chromosome 3q11-q13.3. Our mapping data suggest that the rho polypeptide genes, which are thought to share a common ancestor with GABA(A) receptor subunit genes, diverged at an early stage in the evolution of this gene family.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 3*
  • Genetic Linkage
  • Humans
  • Molecular Sequence Data
  • Receptors, GABA / genetics*
  • Receptors, GABA-A
  • Receptors, GABA-B*

Substances

  • GABRR2 protein, human
  • Receptors, GABA
  • Receptors, GABA-A
  • Receptors, GABA-B

Associated data

  • GENBANK/Y18994