Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397)

J Med Chem. 1999 Dec 16;42(25):5061-3. doi: 10.1021/jm990517p.

Authors

H Kawamoto¹, S Ozaki, Y Itoh, M Miyaji, S Arai, H Nakashima, T Kato, H Ohta, Y Iwasawa

Affiliation

¹ Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.

PMID: 10602690
DOI: 10.1021/jm990517p

No abstract available

MeSH terms

Animals
Benzimidazoles / chemistry
Benzimidazoles / pharmacology*
Humans
Piperidines / chemistry
Piperidines / pharmacology*
Receptors, Opioid / agonists*
Structure-Activity Relationship

Substances

Benzimidazoles
J 113397
Piperidines
Receptors, Opioid