Long-term safety of hepatic hydroxymethyl glutaryl coenzyme A reductase inhibitors: the role of metabolism-monograph for physicians

Arch Intern Med. 2000 Aug;160(15):2273-80. doi: 10.1001/archinte.160.15.2273.

Authors

M Bottorff¹, P Hansten

Affiliation

¹ College of Pharmacy, University of Cincinnati Medical Center, Cincinnati, OH 45267-0004, USA.

PMID: 10927723
DOI: 10.1001/archinte.160.15.2273

No abstract available

Publication types

Comparative Study
Review

MeSH terms

Cytochrome P-450 Enzyme System / physiology
Dose-Response Relationship, Drug
Drug Interactions
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacokinetics*
Liver / enzymology*
Metabolic Clearance Rate / physiology

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cytochrome P-450 Enzyme System