Abstract
Blood flow and glucose utilization were measured in rat brain after chronic L-NAME treatment followed by acute 7-nitroindazole. Following chronic L-NAME, blood flow was not significantly different from control. Treatment with acute 7-nitroindazole reduced blood flow to the same extent in both chronic saline and L-NAME groups. Glucose utilization was unaffected. These results suggest that residual NOS activity in brain is sufficient to provide tonic, NO-dependent cerebrovascular dilator tone.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cerebrovascular Circulation / drug effects*
-
Cerebrovascular Circulation / physiology
-
Enzyme Inhibitors / pharmacology*
-
Glucose / metabolism*
-
Indazoles / pharmacology*
-
NG-Nitroarginine Methyl Ester / pharmacology*
-
Nitric Oxide Synthase / antagonists & inhibitors*
-
Nitric Oxide Synthase / metabolism
-
Nitric Oxide Synthase Type I
-
Rats
Substances
-
Enzyme Inhibitors
-
Indazoles
-
Nitric Oxide Synthase
-
Nitric Oxide Synthase Type I
-
Nos1 protein, rat
-
Glucose
-
7-nitroindazole
-
NG-Nitroarginine Methyl Ester