Abstract
The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / metabolism*
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Alzheimer Disease / pathology
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Calcium-Binding Proteins*
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Disease Progression
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Frontal Lobe / chemistry
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Frontal Lobe / metabolism
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Frontal Lobe / pathology
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GAP-43 Protein / analysis
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GAP-43 Protein / metabolism
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Humans
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Immunoblotting
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Membrane Glycoproteins / analysis
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Membrane Glycoproteins / metabolism*
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Nerve Tissue Proteins / analysis
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Nerve Tissue Proteins / metabolism*
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Severity of Illness Index
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Synapses / chemistry
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Synapses / metabolism*
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Synaptophysin / chemistry
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Synaptophysin / metabolism
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Synaptotagmins
Substances
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Calcium-Binding Proteins
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GAP-43 Protein
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Membrane Glycoproteins
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Nerve Tissue Proteins
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Synaptophysin
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Synaptotagmins