Abstract
Since their discovery, B1 B cells' origins and developmental pathways have eluded characterization. In the past year, focus on B1 B cells has shifted dramatically from developmental to functional aspects of these cells. Most advances have been made in describing the physiological activities of B1 cells, including their migration, activation by antigen and role in both autoimmunity and malignancy.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens, CD / immunology
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Antigens, CD / metabolism
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B-Lymphocyte Subsets / cytology*
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B-Lymphocyte Subsets / immunology*
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B-Lymphocyte Subsets / metabolism
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CD5 Antigens / immunology
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CD5 Antigens / metabolism
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Cell Differentiation
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Cell Survival
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Humans
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Immunologic Memory
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Lymphocyte Activation
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Membrane Glycoproteins*
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Tetraspanin 29
Substances
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Antigens, CD
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CD5 Antigens
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CD9 protein, human
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Membrane Glycoproteins
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Tetraspanin 29