Coordinate regulation of metabotropic glutamate receptors

S Alagarsamy; S D Sorensen; P J Conn

doi:10.1016/s0959-4388(00)00219-1

Coordinate regulation of metabotropic glutamate receptors

Curr Opin Neurobiol. 2001 Jun;11(3):357-62. doi: 10.1016/s0959-4388(00)00219-1.

Authors

S Alagarsamy¹, S D Sorensen, P J Conn

Affiliation

¹ 1510 Clifton Road, Rollins Research Center Room 5160, Department of Pharmacology, Emory University, Atlanta, GA 30322, USA. salagar@emory.edu

PMID: 11399435
DOI: 10.1016/s0959-4388(00)00219-1

Abstract

Recent studies aimed at identifying the mechanisms that regulate the signaling of metabotropic glutamate receptors (mGluRs) have revealed that both protein kinase and protein phosphatase activity are important in directly modulating mGluR function. The inter-relationship between phosphorylation and dephosphorylation of mGluRs seems to be an important determinant in regulating mGluR function and the subsequent neuromodulatory events elicited by activation of mGluRs.

Publication types

Review

MeSH terms

Animals
Brain / cytology
Brain / physiology
Cells, Cultured
Cyclic AMP-Dependent Protein Kinases / physiology
Glutamic Acid / physiology*
Humans
Nerve Tissue Proteins / drug effects
Nerve Tissue Proteins / physiology*
Phosphorylation
Protein Kinase C / physiology
Protein Processing, Post-Translational / physiology*
Protein Subunits
Receptor Cross-Talk / physiology
Receptors, Metabotropic Glutamate / classification
Receptors, Metabotropic Glutamate / drug effects
Receptors, Metabotropic Glutamate / physiology*
Receptors, N-Methyl-D-Aspartate / physiology
Receptors, Presynaptic / physiology
Signal Transduction / drug effects
Signal Transduction / physiology*

Substances

Nerve Tissue Proteins
Protein Subunits
Receptors, Metabotropic Glutamate
Receptors, N-Methyl-D-Aspartate
Receptors, Presynaptic
Glutamic Acid
Cyclic AMP-Dependent Protein Kinases
Protein Kinase C