Synaptic P2X receptors

Curr Opin Neurobiol. 2001 Jun;11(3):378-86. doi: 10.1016/s0959-4388(00)00222-1.

Abstract

Over the past two years, ATP has clearly been shown to act as a co-transmitter with GABA, glycine and probably glutamate in the central nervous system. Our understanding of the ATP-gated P2X receptors is progressing rapidly, and the pharmacology, stoichiometry and subunit combinations of heteropolymeric P2X channels has been substantially elucidated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Action Potentials / physiology
  • Adenosine Triphosphate / physiology
  • Animals
  • Brain / physiology
  • Forecasting
  • Humans
  • Ion Channel Gating / drug effects
  • Ion Channel Gating / physiology
  • Ion Channels / physiology
  • Mammals / physiology
  • Models, Neurological
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / immunology
  • Nerve Tissue Proteins / physiology*
  • Neuroglia / drug effects
  • Neuroglia / physiology
  • Protein Kinase C / physiology
  • Protein Subunits
  • Purinergic P2 Receptor Agonists
  • Rats
  • Receptors, GABA / physiology
  • Receptors, Presynaptic / drug effects
  • Receptors, Presynaptic / physiology
  • Receptors, Purinergic P2 / chemistry
  • Receptors, Purinergic P2 / immunology
  • Receptors, Purinergic P2 / physiology*
  • Recombinant Fusion Proteins / physiology
  • Structure-Activity Relationship
  • Synapses / physiology*
  • Synaptic Transmission / physiology*

Substances

  • Ion Channels
  • Nerve Tissue Proteins
  • Protein Subunits
  • Purinergic P2 Receptor Agonists
  • Receptors, GABA
  • Receptors, Presynaptic
  • Receptors, Purinergic P2
  • Recombinant Fusion Proteins
  • Adenosine Triphosphate
  • Protein Kinase C