Abstract
Over the past two years, ATP has clearly been shown to act as a co-transmitter with GABA, glycine and probably glutamate in the central nervous system. Our understanding of the ATP-gated P2X receptors is progressing rapidly, and the pharmacology, stoichiometry and subunit combinations of heteropolymeric P2X channels has been substantially elucidated.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Action Potentials / physiology
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Adenosine Triphosphate / physiology
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Animals
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Brain / physiology
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Forecasting
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Humans
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Ion Channel Gating / drug effects
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Ion Channel Gating / physiology
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Ion Channels / physiology
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Mammals / physiology
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Models, Neurological
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / immunology
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Nerve Tissue Proteins / physiology*
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Neuroglia / drug effects
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Neuroglia / physiology
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Protein Kinase C / physiology
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Protein Subunits
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Purinergic P2 Receptor Agonists
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Rats
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Receptors, GABA / physiology
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Receptors, Presynaptic / drug effects
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Receptors, Presynaptic / physiology
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Receptors, Purinergic P2 / chemistry
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Receptors, Purinergic P2 / immunology
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Receptors, Purinergic P2 / physiology*
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Recombinant Fusion Proteins / physiology
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Structure-Activity Relationship
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Synapses / physiology*
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Synaptic Transmission / physiology*
Substances
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Ion Channels
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Nerve Tissue Proteins
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Protein Subunits
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Purinergic P2 Receptor Agonists
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Receptors, GABA
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Receptors, Presynaptic
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Receptors, Purinergic P2
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Recombinant Fusion Proteins
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Adenosine Triphosphate
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Protein Kinase C