Protein-protein interfaces: mimics and inhibitors

Curr Opin Chem Biol. 2001 Dec;5(6):654-9. doi: 10.1016/s1367-5931(01)00262-9.

Abstract

Many biological processes are mediated by specific molecular recognition between proteins. However, the thermodynamic and structural 'rules' for such recognition are incompletely understood, as is the potential for inhibition by small molecules. Recent progress has included the discovery of small-molecule inhibitors for several targets important in cancer.

Publication types

  • Review

MeSH terms

  • Membrane Proteins / pharmacology
  • Models, Molecular*
  • Molecular Mimicry*
  • Nuclear Proteins*
  • Protein Binding
  • Protein Conformation
  • Proteins / agonists
  • Proteins / antagonists & inhibitors
  • Proteins / chemistry*
  • Proto-Oncogene Proteins / pharmacology
  • Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors
  • Proto-Oncogene Proteins c-bcl-2 / chemistry
  • Proto-Oncogene Proteins c-mdm2
  • Tumor Suppressor Protein p53 / antagonists & inhibitors
  • Tumor Suppressor Protein p53 / chemistry
  • bcl-2 Homologous Antagonist-Killer Protein

Substances

  • Membrane Proteins
  • Nuclear Proteins
  • Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Tumor Suppressor Protein p53
  • bcl-2 Homologous Antagonist-Killer Protein
  • Proto-Oncogene Proteins c-mdm2