Abstract
Adrenomedullin (AM), alpha- and beta-calcitonin gene-related peptide (CGRP), amylin and calcitonin (CT) are structurally and functionally related peptides. The structure of a receptor for CT (CTR) was elucidated in 1991 through molecular cloning, but the structures of the receptors for the other three peptides had yet to be elucidated. The discovery of receptor-activity-modifying proteins (RAMP) 1 and -2 and their co-expression with an orphan receptor, calcitonin receptor-like receptor (CRLR) has led to the elucidation of functional CGRP and AM receptors, respectively. RAMP1 and -3 which are co-expressed with CTR revealed two amylin receptor isotypes. Molecular interactions between CRLR and RAMPs are involved in their transport to the cell surface. Heterodimeric complexes between CRLR or CTR and RAMPs are required for ligand recognition.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adrenomedullin
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Amyloid / metabolism
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Animals
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Calcitonin / metabolism
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Calcitonin Gene-Related Peptide / metabolism
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Calcitonin Receptor-Like Protein
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Humans
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Intracellular Signaling Peptides and Proteins
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Islet Amyloid Polypeptide
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Membrane Proteins / metabolism*
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Peptides / metabolism*
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Receptor Activity-Modifying Protein 1
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Receptor Activity-Modifying Proteins
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Receptors, Adrenomedullin
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Receptors, Calcitonin / metabolism
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Receptors, Peptide / metabolism*
Substances
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Amyloid
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CALCRL protein, human
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Calcitonin Receptor-Like Protein
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Intracellular Signaling Peptides and Proteins
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Islet Amyloid Polypeptide
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Membrane Proteins
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Peptides
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RAMP1 protein, human
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Receptor Activity-Modifying Protein 1
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Receptor Activity-Modifying Proteins
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Receptors, Adrenomedullin
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Receptors, Calcitonin
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Receptors, Peptide
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Adrenomedullin
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Calcitonin
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Calcitonin Gene-Related Peptide