A new trigger for T cells

Mark M Davis

doi:10.1016/s0092-8674(02)00865-6

A new trigger for T cells

Cell. 2002 Aug 9;110(3):285-7. doi: 10.1016/s0092-8674(02)00865-6.

Author

Mark M Davis¹

Affiliation

¹ Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. mdavis@cmgm.stanford.edu

PMID: 12176315
DOI: 10.1016/s0092-8674(02)00865-6

Abstract

Understanding the early events in T cell activation and signaling is an active area of research. A recent study has described a new trigger for T cell activation, involving a TCR-ligand-induced conformational change in CD3epsilon that permits binding of the adaptor protein Nck.

Publication types

Review

MeSH terms

Adaptor Proteins, Signal Transducing
Animals
CD3 Complex*
Cell Membrane / immunology
Cell Membrane / ultrastructure
Humans
Immune System / immunology*
Lymphocyte Activation / genetics
Lymphocyte Activation / immunology*
Oncogene Proteins / genetics
Oncogene Proteins / immunology*
Protein Binding / immunology
Receptors, Antigen, T-Cell / genetics
Receptors, Antigen, T-Cell / immunology*
T-Lymphocytes / cytology
T-Lymphocytes / immunology*

Substances

Adaptor Proteins, Signal Transducing
CD3 Complex
CD3E protein, human
Nck protein
Oncogene Proteins
Receptors, Antigen, T-Cell